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The following is a sample from Volume 1 Issue 1 (Revised) of NanoClarity.

Volume 1 Issue 1 August 2006 (updated)
www.nanoclarity.com

INTRODUCING NanoClarity:

NanoClarity explains, clarifies and values nanotechnology - that amazing new technology that the entire world is developing. Nanotechnology will radically change everything you know and do over the next decade. The first three issues of NanoClarity should ground you in nanotechnology using understandable language. They explain why you need to stay ahead of the curve as nanotechnology increasingly affects your life over the next few years. Many lucrative opportunities are there for the perceptive. I will give you insights to find and evaluate them.

This issue....THE TECHNOLOGY OF NANOTECHNOLOGY.
Issue 2..........THE EXPANDING MARKETS AND OPPORTUNITIES IN NANOTECHNOLOGY.
Issue 3..........THE WONDERFUL ECONOMICS AND DISRUPTIVE EFFECTS OF NANOTECHNOLOGY - OUR EVALUATION CRITERIA.

These are basic reference issues. Take your time reading them. Keep them for referral later. Our full year, 12 issue program is listed on our web site under Topics.

Alan's Picture From The Publisher

NanoClarity is not a news report; it is not an investment advisory (although the values and opinion in NanoClarity may be used in investment considerations); it is not a "shill" sheet - picking and recommending companies and/or technologies in which the publisher has a stake or that he is underwriting. Rather, NanoClarity is designed as a clarifying document offering objective insight, evaluation and opinion on what is going on in the nanotechnology world. I intend to clarify the meaning, merit and worth of all I discuss projecting out three to five years. I will use similar reasoning and present concrete measurements for all companies evaluated. I will explain and praise that which is promising or good. I also will expose and debunk that which is phony or flawed. If I make some investors, venture capitalists, institutions or entrepreneurs unhappy, I will have done my job. No one in the dot.com bubble was outspoken enough to identify the emperor's new clothes hype surrounding most of the "so-called" new developments or businesses formed - like Pets.com, Groceries.com, the redundant expenditures in glass transmission capacity, etc. From its outset, NanoClarity will provide proper support - and proper debunking.

The four questions I am most regularly asked are: What is nanotechnology? Why is it so important? Is Nanotechnology now or sometime in the future? and Can I make any money in nanotechnology? (Usually the last question by a private investor looking for the next hot deal.) I am not directly going to answer the last question - but I will answer the first three in depth and, I hope, with wisdom so that my subscriber can soundly answer the fourth question on his or her own.

NanoClarity intends to be the definitive objective commentary on developments and companies in nanotechnology. That is my commitment to you, our subscribers. If NanoClarity ever strays from that purpose, please let me know - in the harshest of terms - and I will respond.Alan Shalleck, Publisher.

IN THIS ISSUE

OPINION

THE CLASSIC NANOTECHNOLOGY VISION:

THE CAPABILITY
THE CHALLENGE
THE BENEFIT
THE ETHICAL AND ENVIRONMENTAL RISKS

THE TECHNOLOGY OF NANOTECHNOLOGY

WHAT IS NANOTECHNOLOGY?
FROM OLD AND BIG (RELATIVELY) TO NEW AND SMALL (VERY SMALL)

TOP DOWN (OLD WAY)
BOTTOM UP (NEW WAY)
VERY, VERY, VERY SMALL

WHY CAN NANOTECHNOLOGY CREATE NEW STUFF

NEW FORCES APPLY
NEW BONDING AND INTERACTING OPPORTUNITIES
NEW INSTRUMENTATION REQUIRED
MASS MANUFACTURING - SELF ASSEMBLY AND SELF REPLICATION

YOU ARE ALREADY USING NANOPRODUCTS
ORGANIC AND INORGANIC ARE NEEDED TOGETHER – A FIRST
NANOSENSORS

DNA SENSORS

NANOMEDICINE AND NANOBOTS

QUANTUM DOTS
BIOBOTS

HOW A BIOBOT GETS ENERGY
HOW A BIOBOT MOVES
HOW A BIOBOT KNOWS WHERE TO GO AND WHAT TO DO
HOW A BIOBOT GETS RID OF ITSELF AND CLEARS THE BODY

NANOENERGY

NANOELECTRONICS, NANOSEMI-CONDUCTORS AND NANOCOMPUTERS

INTELLECTUAL PROPERTY

SUMMARY AND CONCLUSIONS

APPENDIX 1 – GLOBAL COMPETITIVENESS

APPENDIX 2 - TYPICAL APPLICATIONS AREAS OF NANOTECHNOLOGY

OPINION:

I believe nanotechnology is the world altering technology of the 21st century. Over $25 Billion in government funding worldwide is currently directed toward nanotechnology. Over 2/3 of all new discoveries and developments in nanotechnology are expected to come from outside the United States! The entire world is in a race to create a nanotechnology economy. Those nations formally committed to a national objective are listed in Appendix I. The nations that most succeed in nanotechnology should dominate the latter half of this century. U.S. worldwide economic leadership is no longer assured.

Today, nanotechnology is at the point of takeoff as a practical, influential series of technological, product and structural changes that will increasingly shape our personal lives. It holds the potential to revolutionize the ways in which we do things. Nanotechnology's "disruptive technology" (technology that radically upsets existing economic patterns) is a quantum leap in capability for society. With its amazing future and positive effects, nanotechnology also holds the potential for extreme hype, outrageous fraud, market excess, and massive financial losses a la the dot.com era. The rewards are there for those who are clairvoyant - but be smart and be wary. The bottom line is that nanotechnology is real technology and, with NanoClarity, I will help you to judge between the reality and the hype.

THE CLASSIC NANOTECHNOLOGY VISION:
To begin to understand nanotechnology you have to imagine the vision voiced almost two decades ago by Dr. Eric Drexler*. That vision begins like this:

THE CAPABILITY

Nanotechnology - the science and manipulation to very specific applications of the very small at the level of the individual atom … nano comes from the Greek word for "dwarf" ... can open up a world of new and vastly improved capabilities, products, systems and services by building into materials and molecules incredibly multiplied capabilities. Nanotechnology is the pathway to a major jump in technological achievement across the entire economy.

In nanotechnology developers work from the "bottom up" to create those capabilities from the first atom assembled. Nanotechnology is truly the creation of "designer molecules" - atom by atom. In nanotechnology, you can tailor new molecules or systems to virtually any property you might require. You build every need fulfillment in from the beginning. It is a very efficient process. For example, using nanotechnology, developers can create:

new metals that have hugely increased strength and unique properties;
drugs perfectly tailored to specific diseases or maladies delivered in unique ways;
new coatings that are harder or more flexible than anything imagined today;
very small but incredibly capable analytic testing devices;
laboratories on a chip for immediate medical diagnosis,
smart therapeutic devices that can safely roam in your blood stream to identify, isolate, cure and/or destroy diseased cells before they become noticed;
ultra-small, incredibly capable, high speed bio-computers, orders of magnitude more powerful than today’s silicon based supercomputers;
new clothing materials with stain repellent, disease prevention and communication capabilities built into the fibers;
better and smaller sensors for everything;
new exotic military materials and capabilities, etc.

Nanotechnology is extraordinary. It is the ultimate technological revolution. Every part of worldwide society will be changed by nanotechnology in this century.

THE CHALLENGE

The second part of the Drexler vision is that different methodologies are needed to make these new tiny molecules and materials at low cost in mass production amounts. Currently we cannot easily see or manipulate small amounts of nanostructures - they are too tiny -let alone produce them massively and reliably in production quantities. No current machine or process fulfills the production dream. The nanotechnology vision calls for "self assembly" and "duplication capability" to be built into most new nanomolecules. The model for self-assembly and duplication is of course the human cell which already can reproduce itself as well as make nanosized proteins, enzymes and other life supporting molecules in mass amounts without assistance. (More on the merger of bio and non-organic worlds below.)

THE BENEFIT

The third part of the Drexler vision is the benefit we will receive as a society from nanotechnology. Using nanotechnology, we will create new products and industries putting many new people to work and improving the general standard of living worldwide. We will create new ways to do things that will disrupt and/or make current ways more efficient. (E.g. General Motors now uses nanoparticles in its paint because nanoparticle-infused paint will stick to metal and plastic significantly better than current paint using less volume of paint per car. Extrapolating to all paint and coating processes, this one new "nanotechnology based" process structurally changes the entire paint and coatings industry.)

Generalizing, as nanotechnology penetrates society it will change industries and services, eliminating major portions of existing industries and accomplish results no other materials or systems currently allow. (E.g. the proposal to build a space "elevator" by using ultra-strong carbon nanotubes in alloy to construct nanotube picture a ribbon and tether 200 miles into space - to be used as an "elevator" to place satellites and other materials directly into orbit making the billion dollar space launch booster industry irrelevant.) Most potential nanotechnology developments eventually disrupt broad industry structures and eliminate one or more major industry levels (e.g. distributors or clinical testing laboratories). Long term, a restructured worldwide society massively benefits from nanotechnology.

THE ETHICAL AND ENVIRONMENTAL RISKS
The last part of Drexler's nanotechnology vision is that the nanorevolution will be green, painless and positive. To this I say, "Not so fast"… many ethical questions are rightfully raised disputing this part of the nanotechnology vision. Controlling the self-assembly attribute alone is the subject of ethical concerns being raised today regarding nanotechnology's adoption by the world. A recent novel by author Michael Crichton, PREY, in a flawed view of the technology, dealt graphically with some of these ethical questions. I will devote an entire issue of NanoClarity to The Ethical and Risk Questions in Nanotechnology later in the year.

That quickly sums up the nanotechnology vision voiced by Dr. K. Eric Drexler in 1986*. Most scientists and futurists initially thought Drexler Pollyannaish but in 2004, many of his dreams are becoming more realizable every day.
*To read more about the vision for nanotechnology, read Dr. K. Eric Drexler’s 1986 book, “Engines of Creation the Coming Era of Nanotechnology,” now in paperback by Anchor Books.

"CONTINUED FOR SUBSCRIBERS ONLY"